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Environmental stress forces populations to move away from oppressive regions and look for desirable environments. Different species can respond to the same spatial distributions of resources and toxicants with distinct movement strategies. However, the optimal behavioral strategy may differ when resources and stressors occur simultaneously or if they are distributed in different patterns. We compared the total abundance of two strains ofCaenorhabditis eleganswith different locomotion speeds as they forage in various spatial distributions of resources and toxicants. Informed by the experimental observations, we proposed a new two‐state population model, wherein nutrient uptake and reproduction are modeled separately, as driven by the spatial distribution of resources and toxicants. We found that fast movers had an advantage when either the toxicant coverage or the overlap between toxicants and resources was increased. Also, to assess the effectiveness of designing refuges to conserve species in stressful cases, we compared different preferences of locations of refuge areas according to movement strategies. Our mathematical model explained that fast movement enables individuals to consume resources at one location and reproduce at a separate location to avoid the toxicant‐induced reduction in reproduction rate, which underlined its observed advantage in certain experimental settings. This work provided a better model to predict how species with different movement strategies respond to environmental stressors in natural systems. 

Abstract We present the discovery of 11 new transiting brown dwarfs (BDs) and low-mass M dwarfs from NASA’s Transiting Exoplanet Survey Satellite (TESS) mission: TOI-2844, TOI-3122, TOI-3577, TOI-3755, TOI-4462, TOI-4635, TOI-4737, TOI-4759, TOI-5240, TOI-5467, and TOI-5882. They consist of five BD companions and six very-low-mass stellar companions ranging in mass from 25M_Jto 128M_J. We used a combination of photometric time-series, spectroscopic, and high-resolution imaging follow-up as a part of the TESS Follow-up Observing Program (or TFOP) to characterize each system. With over 50 transiting BDs confirmed, we now have a large enough sample to directly test different formation and evolutionary scenarios. We provide a renewed perspective on the transiting “brown dwarf desert” and its role in differentiating between planetary and stellar formation mechanisms. Our analysis of the eccentricity distribution for the transiting BD sample does not support previous claims of a transition between planetary and stellar formation at ∼42M_J. We also contribute a first look into the metallicity distribution of transiting companions in the range 7–150M_J, showing that this does not support a ∼42M_Jtransition too. Finally, we also detect a significant lithium absorption feature in one of the BD hosts (TOI-5882). However, we determine that the host star is likely old based on rotation, kinematic, and photometric mdeasurements. We therefore claim that TOI-5882 may be a candidate for planetary engulfment. 

Mechanosensory feedback of the internal reproductive state drives decisions about when and where to reproduce. For instance, stretch in the Drosophila reproductive tract produced by artificial distention or from accumulated eggs regulates the attraction to acetic acid to ensure optimal oviposition. How such mechanosensory feedback modulates neural circuits to coordinate reproductive behaviors is incompletely understood. We previously identified a stretch-dependent homeostat that regulates egg laying in Caenorhabditis elegans. Sterilized animals lacking eggs show reduced Ca2+ transient activity in the presynaptic HSN command motoneurons that drive egg-laying behavior, while animals forced to accumulate extra eggs show dramatically increased circuit activity that restores egg laying. Interestingly, genetic ablation or electrical silencing of the HSNs delays, but does not abolish, the onset of egg laying, with animals recovering vulval muscle Ca2+ transient activity upon egg accumulation. Using an acute gonad microinjection technique to mimic changes in pressure and stretch resulting from germline activity and egg accumulation, we find that injection rapidly stimulates Ca2+ activity in both neurons and muscles of the egg-laying circuit. Injection-induced vulval muscle Ca2+ activity requires L-type Ca2+ channels but is independent of presynaptic input. Conversely, injection-induced neural activity is disrupted in mutants lacking the vulval muscles, suggesting "bottom-up" feedback from muscles to neurons. Direct mechanical prodding activates the vulval muscles, suggesting that they are the proximal targets of the stretch-dependent stimulus. Our results show that egg-laying behavior in C. elegans is regulated by a stretch-dependent homeostat that scales postsynaptic muscle responses with egg accumulation in the uterus. 

Abstract We report the validation of multiple planets transiting the nearby (d= 12.8 pc) K5V dwarf HD 101581 (GJ 435, TOI–6276, TIC 397362481). This system consists of at least two Earth-size planets whose orbits are near a mutual 4:3 mean-motion resonance, HD 101581 b ( $R_p={0.956}_{-0.061}^{+0.063}{R}_{\oplus }$,P= 4.47 days) and HD 101581c ( $R_p={0.990}_{-0.070}^{+0.070}{R}_{\oplus }$,P= 6.21 days). Both planets were discovered in Sectors 63 and 64 TESS observations and statistically validated with supporting ground-based follow-up. We also identify a signal that probably originates from a third transiting planet, TOI-6276.03 ( $R_p={0.982}_{-0.098}^{+0.114}{R}_{\oplus }$,P= 7.87 days). These planets are remarkably uniform in size and their orbits are evenly spaced, representing a prime example of the “peas-in-a-pod” architecture seen in other compact multiplanet systems. AtV= 7.77, HD 101581 is the brightest star known to host multiple transiting planets smaller than 1.5R_⊕. HD 101581 is a promising system for atmospheric characterization and comparative planetology of small planets. 

Abstract Activated Gαq signals through phospholipase-Cβ and Trio, a Rho GTPase exchange factor (RhoGEF), but how these distinct effector pathways promote cellular responses to neurotransmitters like serotonin remains poorly understood. We used the egg-laying behavior circuit of Caenorhabditis elegans to determine whether phospholipase-Cβ and Trio mediate serotonin and Gαq signaling through independent or related biochemical pathways. Our genetic rescue experiments suggest that phospholipase-Cβ functions in neurons while Trio Rho GTPase exchange factor functions in both neurons and the postsynaptic vulval muscles. While Gαq, phospholipase-Cβ, and Trio Rho GTPase exchange factor mutants fail to lay eggs in response to serotonin, optogenetic stimulation of the serotonin-releasing HSN neurons restores egg laying only in phospholipase-Cβ mutants. Phospholipase-Cβ mutants showed vulval muscle Ca2+ transients while strong Gαq and Trio Rho GTPase exchange factor mutants had little or no vulval muscle Ca2+ activity. Treatment with phorbol 12-myristate 13-acetate that mimics 1,2-diacylglycerol, a product of PIP2 hydrolysis, rescued egg-laying circuit activity and behavior defects of Gαq signaling mutants, suggesting both phospholipase-C and Rho signaling promote synaptic transmission and egg laying via modulation of 1,2-diacylglycerol levels. 1,2-Diacylglycerol activates effectors including UNC-13; however, we find that phorbol esters, but not serotonin, stimulate egg laying in unc-13 and phospholipase-Cβ mutants. These results support a model where serotonin signaling through Gαq, phospholipase-Cβ, and UNC-13 promotes neurotransmitter release, and that serotonin also signals through Gαq, Trio Rho GTPase exchange factor, and an unidentified, phorbol 12-myristate 13-acetate-responsive effector to promote postsynaptic muscle excitability. Thus, the same neuromodulator serotonin can signal in distinct cells and effector pathways to coordinate activation of a motor behavior circuit. 

Abstract Young eclipsing binaries (EBs) are powerful probes of early stellar evolution. Current models are unable to simultaneously reproduce the measured and derived properties that are accessible for EB systems (e.g., mass, radius, temperature, and luminosity). In this study we add a benchmark EB to the pre-main-sequence population with our characterization of TOI 450 (TIC 77951245). Using Gaia astrometry to identify its comoving, coeval companions, we confirm TOI 450 is a member of the ∼40 Myr Columba association. This eccentric (e= 0.2969), equal-mass (q= 1.000) system provides only one grazing eclipse. Despite this, our analysis achieves the precision of a double-eclipsing system by leveraging information in our high-resolution spectra to place priors on the surface-brightness and radius ratios. We also introduce a framework to include the effect of star spots on the observed eclipse depths. Multicolor eclipse light curves play a critical role in breaking degeneracies between the effects of star spots and limb-darkening. Including star spots reduces the derived radii by ∼2% from a unspotted model (>2σ) and inflates the formal uncertainty in accordance with our lack of knowledge regarding the starspot orientation. We derive masses of 0.1768( ± 0.0004) and 0.1767( ± 0.0003)M_⊙, and radii of 0.345(±0.006) and 0.346(±0.006)R_⊙for the primary and secondary, respectively. We compare these measurements to multiple stellar evolution isochones, finding good agreement with the association age. The MESA MIST and SPOTS (f_s= 0.17) isochrones perform the best across our comparisons, but detailed agreement depends heavily on the quantities being compared. 

Abstract Egg laying in the nematode worm Caenorhabditis elegans is a two-state behavior modulated by internal and external sensory input. We have previously shown that homeostatic feedback of embryo accumulation in the uterus regulates bursting activity of the serotonergic HSN command neurons that sustains the egg-laying active state. How sensory feedback of egg release signals to terminate the egg-laying active state is less understood. We find that Gαo, a conserved Pertussis Toxin-sensitive G protein, signals within HSN to inhibit egg-laying circuit activity and prevent entry into the active state. Gαo signaling hyperpolarizes HSN, reducing HSN Ca2+ activity and input onto the postsynaptic vulval muscles. Loss of inhibitory Gαo signaling uncouples presynaptic HSN activity from a postsynaptic, stretch-dependent homeostat, causing precocious entry into the egg-laying active state when only a few eggs are present in the uterus. Feedback of vulval opening and egg release activates the uv1 neuroendocrine cells which release NLP-7 neuropeptides which signal to inhibit egg laying through Gαo-independent mechanisms in the HSNs and Gαo-dependent mechanisms in cells other than the HSNs. Thus, neuropeptide and inhibitory Gαo signaling maintain a bi-stable state of electrical excitability that dynamically controls circuit activity in response to both external and internal sensory input to drive a two-state behavior output. 

Abstract Hot Jupiters were many of the first exoplanets discovered in the 1990s, but in the decades since their discovery the mysteries surrounding their origins have remained. Here we present nine new hot Jupiters (TOI-1855 b, TOI-2107 b, TOI-2368 b, TOI-3321 b, TOI-3894 b, TOI-3919 b, TOI-4153 b, TOI-5232 b, and TOI-5301 b) discovered by NASA’sTESSmission and confirmed using ground-based imaging and spectroscopy. These discoveries are the first in a series of papers named the Migration and Evolution of giant ExoPlanets survey and are part of an ongoing effort to build a complete sample of hot Jupiters orbiting FGK stars, with a limiting GaiaG-band magnitude of 12.5. This effort aims to use homogeneous detection and analysis techniques to generate a set of precisely measured stellar and planetary properties that is ripe for statistical analysis. The nine planets presented in this work occupy a range of masses (0.55M_J<M_P< 3.88M_J) and sizes (0.967R_J<R_P< 1.438R_J) and orbit stars that have an effective temperature in the range of 5360 K <T_eff< 6860 K with GaiaG-band magnitudes ranging from 11.1 to 12.7. Two of the planets in our sample have detectable orbital eccentricity: TOI-3919 b ( $e={0.259}_{-0.036}^{+0.033}$) and TOI-5301 b ( $e={0.33}_{-0.10}^{+0.11}$). These eccentric planets join a growing sample of eccentric hot Jupiters that are consistent with high-eccentricity tidal migration, one of the three most prominent theories explaining hot Jupiter formation and evolution.